MICROSATELLITE INSTABILITY AND MISMATCH REPAIR SYSTEM
نویسندگان
چکیده
منابع مشابه
DNA mismatch repair, microsatellite instability and cancer.
Mismatch (MMR) repair system plays a significant role in restoration of stability in the genome. Mutations in mismatch repair genes hamper their activity thus bring about a defect in mismatch repair (MMR) mechanism thereby conferring instability in the microsatellite sequences of both the coding and non-coding regions of the genome. Mutated mismatch repair genes result in the expansion or contr...
متن کاملMicrosatellite Instability Use in Mismatch Repair Gene Sequence Variant Classification
Inherited mutations in the DNA mismatch repair genes (MMR) can cause MMR deficiency and increased susceptibility to colorectal and endometrial cancer. Microsatellite instability (MSI) is the defining molecular signature of MMR deficiency. The clinical classification of identified MMR gene sequence variants has a direct impact on the management of patients and their families. For a significant p...
متن کاملMismatch repair system and aging: microsatellite instability in peripheral blood cells from differently aged participants.
Age-related alterations of DNA repair could be involved in the accumulation of genetic damage with age. Few data suggest a possible alteration with age of the mismatch repair system, evidenced by the acquisition of microsatellite instability. We aimed to point out a possible implication of this repair system in the accumulation of genetic damage with age. Peripheral blood cell DNA from 226 part...
متن کاملMicrosatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer.
BACKGROUND Methylation in the promoter region of the DNA mismatch repair genes hMLH1 and hMSH2 and microsatellite instability at three loci were analyzed in the tumor tissue from patients with head and neck cancer. METHODS Microsatellite instability and promoter methylation were investigated by PCR, denaturing-polyacrylamide gel electrophoresis and digestion with methylation-specific restrict...
متن کاملMicrosatellite instability and mismatch-repair protein expression in hereditary and sporadic colorectal carcinogenesis.
Aberrant crypt foci (ACF) are microscopic clusters of altered colonic crypts considered premalignant lesions in the large bowel. Genomic instability at short tandem repeats in the DNA, referred to as microsatellite instability (MSI) is the hallmark of hereditary nonpolyposis colorectal carcinoma (HNPCC) caused by mutations in DNA mismatch-repair genes, mostly hMLH1 and hMSH2. In this study, we ...
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ژورنال
عنوان ژورنال: The Japanese Journal of Urology
سال: 1998
ISSN: 0021-5287,1884-7110
DOI: 10.5980/jpnjurol1989.89.917